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Sharapova was born in 1987 to Yuri and Yelena, ethnic Belarusians, in the town of Nyagan' in Siberia, Russia. Her parents moved from Gomel, Belarus after the Chernobyl nuclear accident in 1986 affected the region When Sharapova was two, the family moved to Sochi where her father befriended Aleksandr Kafelnikov, whose son Yevgeny would go on to win two Grand Slam singles titles and became Russia's first ever World No. 1 tennis player. Aleksandr gave Sharapova her first tennis racket at the age of four, where upon she began practicing regularly with her father in a local park. She took her first tennis lessons with veteran Russian coach Yuri Yutkin, who was instantly impressed when he first saw her, noting her "exceptional hand-eye co-ordination."

At the age of seven, Sharapova attended a tennis clinic in Moscow run by Martina Navrátilová, who recommended professional training at the Nick Bollettieri Tennis Academy in Florida, which had previously trained players such as Andre Agassi, Monica Seles and Anna Kournikova. With money tight, Yuri was forced to borrow the sum that would allow him and his daughter, neither of whom could speak English, to travel to America, which they finally did in 1994.Visa restrictions prevented Sharapova's mother from joining them for two years Arriving in Florida with just $700 to his name,Sharapova's father took various low-paying jobs, including dish-washing, to fund her lessons until she was old enough to be admitted to the academy. In 1995, she was signed by IMG, who agreed to pay the annual tuition fee of $35,000 for Sharapova to stay at the academy, allowing her to finally enroll at the age of 9.

After playing two exhibition tournaments in Asia, Sharapova officially began her season at theAustralian Open, where she was upset in her first round by Maria Kirilenko. The loss meant that for the first time since 2003, Sharapova had lost her opening match at a Grand Slam event.Immediately bouncing back, she competed in the Cellular South Cup, winning her 21st career WTA title and first of the year.

At the BNP Paribas Open, Sharapova lost in the third round to Zheng Jie, aggravating a bruised bone on her right elbow in the process, which resulted in her eventual withdrawal from the Sony Ericsson Open, and the Family Circle Cup.

Returning at the 2010 Mutua Madrileña Madrid Open, Sharapova lost in the first round to Lucie Šafářová. She continued her French Open preparation at the Internationaux de Strasbourg with her first title on red clay and 22nd overall title^. Her brief clay season culminated with a third round loss to four-time champion Justine Henin at the French Open. It was her seventh loss to the Belgian in ten career meetings.

Sharapova began her preparations for Wimbledon by making the final of the AEGON Classic for the fourth time since 2007, losing there to Li Na. As the 16th seed at Wimbledon, she made it to the fourth round before losing to world No. 1 and eventual champion Serena Williams, despite having three set points in the opening set.The match was seen as another encouraging performance for Sharapova, with some stating their belief that she was approaching the form that would see her contending for Grand Slams once more, and Sharapova herself stating she feels that she is "in a much better spot than I was last year."

Sharapova started the US Open Series campaign at the Stanford. She advanced to the finals before losing to World No. 18 Victoria Azarenka in straight sets. Her next tournament was at the Western and Southern Financial Group Women's Open. Again, she made it to the finals, this time losing to Kim Clijsters in three sets.

At the 2010 U.S. Open, Sharapova made it to the round of 16, before losing to top-seeded Caroline Wozniacki.

Her last two tournaments of the season would end in disappointment. She played in the Toray Pan Pacific Open in Tokyo, where she was upset in the first round by 39-year-old Kimiko Date Krumm. Her last tournament of the year would be the China Open, she would beat Bulgarian Tsvetana Pironkova in the 1st round, but she would once again be upset, this time in the 2nd round to fellow Russian Elena Vesnina. Days later she announced the end of her 2010 season. She would end the year at #18 in the world.